A DIFFERENT APPROACH IN A CASE OF RECURRENT PURPURA.

Autor: Ribeiro, Joana Filipe, Virtuoso, João, Pinto, Ana, Oliveira, Rita S., Ferreira, Joana, Salgado, Manuel
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Zdroj: Pediatric Oncall Journal; Jan-Mar2024, Vol. 21 Issue 1, p51-53, 3p
Abstrakt: Henoch-Schönlein Purpura (HSP) is an acute, systemic, immune complexmediated leukocytoclastic vasculitis and the most common vasculitis of childhood. HSP is typically self-limited, although some patients experience one or more recurrences. We presented a 16-year-old male, with palpable purpura, abdominal pain and arthralgia, who was diagnosed with HSP. Due to intense and persisting abdominal pain, a high-dose oral prednisolone was initiated, resulting in clinical improvement. However, every attempt at weans off of prednisolone resulted in disease relapse. Combination therapy with colchicine allowed the discontinuation of corticosteroid therapy, and no relapses of the disease was observed. The management of HSP cases with an unusual and complicated presentation remains controversial. However, several cases of successful treatment using immunomodulatory therapy have been reported. The use of colchicine has enabled the successful tapering off prednisolone, reduced its side effects, and prevented further recurrences. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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