| Abstrakt: |
Objective To explore the causal relationship between the characteristics of glycemic traits (fasting blood glucose, fasting insulin, glycosylated hemoglobin, and insulin resistance) and benign colorectal neoplasm (colorectal adenomas, benign rectal neoplasm, and benign colon neoplasm). Methods The instrumental variables of blood glucose characteristics were extracted from MAGIC and GLGCL alliance, and the genome-wide data of colorectal benign tumors came from Finn-Gen alliance. In this study, random effect inverse-variance weighted method (IVW), MR-Egger regression, and weighted median method (WMM) were used to analyze the causal relationship between four glycemic traits and benign colorectal neoplasm. Results The results of IVW model showed that there was no causal relationship between fasting blood glucose (OA =0.999, 95%CI: 0.997-1.001), fasting insulin (OA=1.002, 95_CI: 0.998-1.006), glycosylated hemoglobin (CI=1.001, 95%CI: 0.999-1.004), insulin resistance (OA=0.999, 95%CI: 0.997-1.002), and colorectal adenoma. There was no causal relationship between fasting blood glucose (OA =0.909, 95%CI: 0.684-1.209), fasting insulin (OA=1.220, 95%CI: 0.706-2.107), glycosylated hemoglobin (0A=0.678, 95_CI: 0.440-1.046), insulin resistance (OA=1.161, 95 CI: 0.810-1.663) and rectal benign tumor. There was no causal relationship between fasting blood glucose (OA =0.966, 95%CI: 0.836-1.116), fasting insulin (OA=1.318, 95%CI: 0.906-1.916), glycosylated hemoglobin (OA=1.124, 95%CI: 0.882-1.431), insulin resistance (OA=1.071, 95%CI: 0.875-1.311) and benign tumors of colon. Conclusion There is no evidence of causal relationships of fasting blood glucose, fasting insulin, glycosy- lated hemoglobin, and insulin resistance with colorectal adenomas, benign rectal neoplasm, and benign colon neoplasm. [ABSTRACT FROM AUTHOR] |
