| Autor: |
Parfenova, L. V., Galimshina, Z. R., Gil'fanova, G. U., Alibaeva, E. I., Pashkova, T. M., Kartashova, O. L., Farrakhov, R. G., Aubakirova, V. R., Parfenov, E. V. |
| Předmět: |
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| Zdroj: |
Russian Journal of Bioorganic Chemistry; Apr2024, Vol. 50 Issue 2, p500-507, 8p |
| Abstrakt: |
Objective: Synthesis of a novel conjugate of hyaluronic acid (HA) and the antimicrobial peptide LL-37 and evaluation of its antibacterial activity as an organic coating for titanium implants. Methods: The hybrid molecule HA–LL-37 was prepared by the Michael reaction of HA-SH and the N-maleimide derivative of LL-37. The hybrid compound has been tested as an antimicrobial organic coating for titanium samples with an inorganic sub-layer created by plasma electrolytic oxidization (PEO) of the surface. Results and Discussion: The in vitro studies have demonstrated the antibacterial effect of the hybrid molecule within the inorganic PEO coating, i.e., a significant (p <0.05) suppression of the ability of Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcus faecium, and Escherichia coli to form biofilms. Conclusions: The presented approach can be utilized for the subsequent design and development of non-fouling antimicrobial coatings of implants to decrease the risk of bacteria-induced diseases. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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