Anti-Inflamatory Activities of Novel Chalcone Derivatives.

Autor:	Yalçın, Ergin, Sevin, Sedat, Uyar, Recep, Ayaz, Furkan
Předmět:	CHALCONE FRIEDEL-Crafts reaction ANTI-inflammatory agents PSEUDOPOTENTIAL method ANTINEOPLASTIC agents GLIOBLASTOMA multiforme
Zdroj:	Russian Journal of Bioorganic Chemistry; Apr2024, Vol. 50 Issue 2, p432-443, 12p
Abstrakt:	Objective: Design and synthesis of two chalcone derivatives, evaluation of their anticancer and antiinflamatory activities. Methods: The ring-closure through an intramolecular Friedel-Crafts reaction followed by an alkaline-catalyzed Claisen-Schmidt condensation. MTT assay was conducted in anticancer activity. The chalcone derivatives tested for anti-inflammatory immunomodulatory potential by measuring pro-inflammatory cytokines production levels. Results and Discussion: Both compounds displayed anti-inflammatory effects on activated mammalian cells without being cytotoxic. Their low toxicity resulted in high IC50 values in glioblastoma cells, indicating they are safe anti-inflammatory agents, yet lack anti-cancer properties. Conclusions: Synthesized and characterized two chalcone derivatives that displayed comparable anti-inflammatory effects, reducing TNF, IL6, GMCSF, and IL12p40 levels without harming macrophages. Their high IC50 values in glioblastoma cells suggest low toxicity and highlight their potential as effective anti-inflammatory agents [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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