| Autor: |
Ramakrishna, B., Karthik, B., Kumar, B. Ashok, Kumar, T. Kranthi |
| Předmět: |
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| Zdroj: |
Russian Journal of Bioorganic Chemistry; Apr2024, Vol. 50 Issue 2, p282-292, 11p |
| Abstrakt: |
Objective: Synthesis of some new coumarin-thiazolidine-2,4-dione-1,2,3-triazoles and evaluation of their anti-lung cancer activity. Methods: Well-known reaction like Knoevenagel condensation and Cu (I) catalyzed azide-alkyne cycloaddition were used. MTT assay was used in anticancer activity. Autodock tools were used foe docking studies. Results and Discussion: The fourteen compounds were screened against A549 and NCI-H460 and compared with Doxorubicin. In addition to this tubulin polymerization inhibition assay and docking studies were performed on some active compounds. Conclusions: Synthesized some new 1,2,3-triazole hybrids and tested their anticancer activity and screened for binding interaction with tubulin. Some of the compounds were found active. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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