Ammonium acylhydrazones based on 4,6-di-tert-butyl-2,3-dihydroxybenzaldehyde: synthesis, possibilities of functionalization, and evaluation of biological activity.

Autor:	Bogdanov, A. V., Bukharov, S. V., Yusupov, A. N., Litvinov, I. A., Voloshina, A. D., Tagasheva, R. G., Kolpakova, E. V.
Předmět:	GRAM-negative bacteria AMMONIUM CANDIDA albicans PSEUDOMONAS aeruginosa ESCHERICHIA coli ANTI-infective agents
Zdroj:	Russian Chemical Bulletin; Mar2024, Vol. 73 Issue 3, p704-713, 10p
Abstrakt:	The reaction of 4,6-di-tert-butyl-2,3-dihydroxybenzaldehyde with analogs of Girard's reagents was used to synthesize new water-soluble ammonium acylhydrazones as individual EC=N,synN-C(O) isomers. The introduction of an additional sterically hindered phenolic moiety into ammonium N-acylhydrazone leads to the emergence of antimicrobial activity against gram-negative pathogens of bacterial (Pseudomonas aeruginosa, Escherichia coli) and fungal origin (Candida albicans). [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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