| Autor: |
Kang, Eun-Jung, Kim, Jae-Hoon, Kim, Young Eun, Lee, Hana, Jung, Kwang Bo, Chang, Dong-Ho, Lee, Youngjin, Park, Shinhye, Lee, Eun-Young, Lee, Eun-Ji, Kang, Ho Bum, Rhyoo, Moon-Young, Seo, Seungwoo, Park, Sohee, Huh, Yubin, Go, Jun, Choi, Jung Hyeon, Choi, Young-Keun, Lee, In-Bok, Choi, Dong-Hee |
| Předmět: |
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| Zdroj: |
Nature Communications; 4/6/2024, Vol. 15 Issue 1, p1-20, 20p |
| Abstrakt: |
Akkermansia muciniphila has received great attention because of its beneficial roles in gut health by regulating gut immunity, promoting intestinal epithelial development, and improving barrier integrity. However, A. muciniphila-derived functional molecules regulating gut health are not well understood. Microbiome-secreted proteins act as key arbitrators of host-microbiome crosstalk through interactions with host cells in the gut and are important for understanding host-microbiome relationships. Herein, we report the biological function of Amuc_1409, a previously uncharacterised A. muciniphila-secreted protein. Amuc_1409 increased intestinal stem cell (ISC) proliferation and regeneration in ex vivo intestinal organoids and in vivo models of radiation- or chemotherapeutic drug-induced intestinal injury and natural aging with male mice. Mechanistically, Amuc_1409 promoted E-cadherin/β-catenin complex dissociation via interaction with E-cadherin, resulting in the activation of Wnt/β-catenin signaling. Our results demonstrate that Amuc_1409 plays a crucial role in intestinal homeostasis by regulating ISC activity in an E-cadherin-dependent manner and is a promising biomolecule for improving and maintaining gut health. Microbiome-secreted proteins act as key modulators of host-microbiome crosstalk. Here, the authors show that Amuc_1409 protein, secreted from Akkermansia muciniphila, plays a key role in intestinal homeostasis by regulating intestinal stem cells through interaction with E-cadherin, indicating its potential as a biomolecule for improving gut health. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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