| Autor: |
Shahin, Nisreen Abu, Alhessa, Ahmad, Alhusani, Tasneem, Kilani, Akram, Alqatawneh, Dana, Qarajeh, Ahmad, Omar, Yousef, Al-Sanouri, Mohammad, Barakat, Tamer, Abdelrahim, Bahaa, Awad, Heyam |
| Předmět: |
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| Zdroj: |
Jordan Journal of Biological Sciences; Mar2024, Vol. 17 Issue 1, p29-36, 8p |
| Abstrakt: |
Background. Colorectal cancer (CRC) remains a major cause of cancer-related morbidity and mortality worldwide. Recently, the pathogenesis of CRC among other cancer types has been linked to lipid metabolism. Fatty acid-binding proteins (FABPs) are a protein-family expressed in multiple tissues and play a crucial role in lipid metabolism. A few recent studies have examined FABPs role in CRC. Our aims are to explore the immunohistochemical expression of fatty acid binding proteins (FABP) 4 and 7 in colorectal cancer, and correlate their expression levels with clinical, histopathological features, and survival. Methods. A retrospective review of colorectal cancer biopsies over a 5-year period was conducted in our institute. Clinical and histological data were collected. Immunohistochemical staining for FABP 4 and 7 was performed using microarray and their expression was evaluated using the Histologic score (HS). The correlations between the expression of FABP 4 and 7 and clinicopathological parameters were determined by Fisher’s exact test. The impact of the expression on the overall survival was determined using Kaplan–Meier survival analysis. Results. 125 CRC tissue biopsy blocks were included. Median follow-up time was 35 months. High FABP4 expression was observed in 107 (85.60%). For FABP7, only 8.8% of cases (11/125) showed high expression. Co-expression of FABP4 and FABP7 occurred in 11 cases (8.8%). FABP7 expression correlated with age (p = 0.001). The median overall survival of patients with high expression of FABP4 was 43.00 ± 3.01 months, whereas patients showing low/negative expression reported a survival of 24.00 ± 6.24 months(p =0.041). No statistically significant association between FABP7 high expression and the overall survival was detected (Log-Rank test, p = 0.086). Conclusion. FABP4 expression in CRC is higher than that of FABP7. FABP7 expression levels negatively correlate with the age of CRC patients. FABP4 expression is associated with a better survival in CRC. No significant association between FABP4 and 7 with tumor grade, stage, or other clinicopathological criteria has been found in this study. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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