An interaction graph approach to gain new insights into mechanisms that modulate cerebrovascular tone.

Autor: Dempsey, Sergio, Argus, Finbar, Maso Talou, Gonzalo Daniel, Safaei, Soroush
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Zdroj: Communications Biology; 4/3/2024, Vol. 7 Issue 1, p1-6, 6p
Abstrakt: Mechanisms to modulate cerebrovascular tone are numerous, interconnected, and spatially dependent, increasing the complexity of experimental study design, interpretation of action-effect pathways, and mechanistic modelling. This difficulty is exacerbated when there is an incomplete understanding of these pathways. We propose interaction graphs to break down this complexity, while still maintaining a holistic view of mechanisms to modulate cerebrovascular tone. These graphs highlight the competing processes of neurovascular coupling, cerebral autoregulation, and cerebral reactivity. Subsequent analysis of these interaction graphs provides new insights and suggest potential directions for research on neurovascular coupling, modelling, and dementia. Presenting mechanisms that modulate cerebral vessel tone as interaction graphs to support research design, interpret study findings, and generate hypotheses on disease. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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