| Autor: |
Wang, Weiwei, Li, Haibo, Guo, Yukun, Zhang, Lihua, Jiang, Wenli, Zheng, Naisheng, Peng, Se, Guan, Xiaolin, Fan, Guang, Shen, Lisong |
| Předmět: |
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| Zdroj: |
Clinical & Experimental Immunology; Feb2024, Vol. 215 Issue 2, p148-159, 12p |
| Abstrakt: |
To investigate the relationship between immune dynamic and graft-versus-host-disease (GVHD) risk, 111 initial diagnostic acute myeloid leukemia patients were reviewed. The flow cytometry data of 12 major lymphocyte subsets in bone marrow (BM) from 60 transplant patients at four different time points were analyzed. Additionally, 90 immune subsets in peripheral blood (PB) of 11 post-transplantation on day 100 were reviewed. Our results demonstrated that transplant patients had longer OS compared to non-transplant patients (P < 0.001). Among transplant patients, those who developed GVHD showed longer OS than those without GVHD (P < 0.05). URD donors and CMV-negative status donors were associated with improved OS in transplant patients (P < 0.05). Importantly, we observed a decreased Th/Tc ratio in BM at initial diagnostic in patients with GVHD compared to those without GVHD (P = 0.034). Receiver operating characteristic analysis indicated that a low Th/Tc ratio predicted an increased risk of GVHD with a sensitivity of 44.44% and specificity of 87.50%. Moreover, an increased T/NK ratio in BM of post-induction chemotherapy was found to be associated with GVHD, with a sensitivity of 75.76% and specificity of 65.22%. Additionally, we observed a decreased percentage of NK1 (CD56-CD16+NK) in PB on day 100 post-transplantation in the GVHD group (P < 0.05). These three indicators exhibit promising potential as specific and useful biomarkers for predicting GVHD. These findings provide valuable insights for the early identification and management of GVHD risk, thereby facilitating the possibility of improving patient outcomes. In this manuscript, the clinical data of 150 untreated acute myeloid leukemia (AML) patients were reviewed. Three immune indicators at different time-points were detected, especially the Th/Tc and T/NK ratio in pre-transplant bone marrow, and NK1 (CD56-CD16 + NK) in peripheral blood on day 100 of the post-transplantation, which may contribute to predicting the graft-versus-host-disease occurrence of AML after transplantation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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