| Abstrakt: |
A new study conducted by researchers at Fujita Health University in Japan has found that altered brain pH and lactate levels may serve as transdiagnostic endophenotypes of neuropsychiatric disorders involving cognitive impairment. The study analyzed brain pH and lactate levels in 109 strains/conditions of 2294 animals with genetic and experimental manipulations relevant to neuropsychiatric disorders. The findings suggest that dysregulated excitation/inhibition balance may contribute to these altered levels and that they may be common features across multiple disorders, including depression, epilepsy, Alzheimer's disease, and some schizophrenia models. The study also found an association between increased brain lactate levels and poor working memory performance. [Extracted from the article] |
