| Abstrakt: |
A recent study conducted by researchers at Wenzhou Medical University in Zhejiang, China, has synthesized a series of novel chalcone analogs derived from syringaldehyde and tested their anticancer activity against various women-specific cancer cell lines. The compounds showed significant cytotoxicity against the cancer cells, with compound 2a exhibiting the most promising anti-proliferation activity and the least cytotoxicity towards normal cells. Compound 2a was found to induce cell apoptosis and G2/M phase arrest, cause DNA damage, and inhibit cell adhesion and migration. It also showed potential in inhibiting tumor growth in mice. The researchers suggest that compound 2a could be a promising lead compound for developing anticancer agents, particularly for ovarian cancer treatment. [Extracted from the article] |
