Discriminating signal from noise: the biological variation of circulating calprotectin in serum and plasma.

Autor: Briers, Marth, Massa, Bo, Vander Cruyssen, Bert, Van Den Bremt, Stefanie, Hofman, Laura, Van Langenhove, Leen, Hoermann, Bernhard, Bossuyt, Xavier, Van Hoovels, Lieve
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Zdroj: Clinical Chemistry & Laboratory Medicine; Apr2024, Vol. 62 Issue 5, pe113-e115, 3p
Abstrakt: This document discusses the biological variation of circulating calprotectin (cCLP) in serum and plasma. Calprotectin is a biomarker that is secreted during inflammation and has gained interest for its potential use in diagnosing and monitoring autoimmune diseases like rheumatoid arthritis. The study aimed to determine the within-subject and between-subject biological variation of cCLP in healthy individuals. The results showed that cCLP levels were higher in serum compared to plasma, and the variation in cCLP levels was lower in plasma samples. Gender and age did not significantly impact cCLP variation. The findings provide valuable information for interpreting cCLP levels in the context of disease diagnosis and treatment response. [Extracted from the article]
Databáze: Complementary Index