| Abstrakt: |
Nimodipine is a dihydropyridine calcium channel blocker that shares the general properties of nifedipine but operates mainly on cerebral blood vessels. Nimodipine is a drug belonging to the Biopharmaceutical Classification System (BCS) class II, which has low solubility and high permeability. This study aimed to investigate the differences in the yield of nanoparticles produced by the dry grinding and wet grinding methods on the physicochemical properties, solubility, and dissolution rate of nimodipine nanoparticles. Furthermore, the nanoparticles were prepared with a nimodipine:HPMC ratio of 1:0.6 using two different methods. Moreover, sample characterization was carried out using Particle Size Analyzer (PSA), Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), X-ray Diffraction (XRD), and Fourier Transform Infrared (FT-IR). In addition, the solubility test was carried out in CO2-free distilled water, while the dissolution rate was carried out in phosphate buffer pH 7.2. It was found that the solubility of pure nimodipine in CO2-free distilled water was 0.339 µg/mL, the physical mixture was 1.948 µg/mL, the dry grinding nanoparticles were 3.367 µg/mL, and the wet grinding nanoparticles were 19.952 µg/mL. Additionally, according to the dissolution test results, the percentage of pure nimodipine dissolution after 60 minutes was 33.947%, the physical mixture was 39.482%, the dry grinding nanoparticles were 49.798%, and the wet grinding nanoparticles were 56.484%. Based on the results of the study, it can be concluded that the nimodipine-HPMC nanoparticles significantly increased the solubility and dissolution rate of nimodipine. [ABSTRACT FROM AUTHOR] |
