| Autor: |
Kazmi, Syed Ayaz, Rauf, Abdul, Latif, Muhammad Zahid, Akhtar, Tasleem, Shahid, Beenish, Khawaja, Sundus, Rasool, Ghulam, Batool, Iqra, Tahir, Muqaddas, Anjum, Zeeshan, Khan, Faiq Nawaz, Sharif, Muhammad Shabir, Farooq, Salma, Liaqat, Jehanzeb |
| Předmět: |
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| Zdroj: |
Journal of Advanced Zoology; 2024, Vol. 45 Issue 3, p497-505, 9p |
| Abstrakt: |
Background: Hepatitis B infection presents a significant global health challenge, with Pakistan experiencing particularly high prevalence rates. Moreover, jaundice is often regarded as a non-threatening metabolic condition by most individuals rather than an infectious concern. Given the strong association between hepatitis B and jaundice, this study aimed to investigate the prevalence of hepatitis B serological markers among individuals with a history of jaundice in the state of AJK, Pakistan. Methods: A cross-sectional study was conducted among 100 participants from the University of Azad Jammu and Kashmir, Muzaffarabad, selected based on the history of jaundice within the last 6 months and aged over 18 years. Data collection included basic ethno-demographic information and screening for hepatitis B using immuno-chromatographic test (ICT) devices forHBsAg, anti-HBc, HBeAg, anti-HCV, and anti-HDV. HBV DNA was extracted for positive HBsAg cases and subjected to PCR amplification. We analyzed the data using GraphPad Prism V. 9.0. Results: Among the participants, 2% tested positive for HBsAg, 1% for HBV DNA, and 1% for HBeAg. Fortunately, none tested positive for Anti-HCV or Anti-HDV. Age-based analysis showed a higher (11.8%) prevalence of hepatitis B markers among participants aged above 25 years. Male participants showed a higher prevalence of HBsAg compared to females (9.5% vs. 0%; p = 0.0056; χ2 = 7.677). District-wise prevalence of hepatitis B varied, with Bagh district showing the highest rate of 10%, while some districts reported no cases. Job-based analysis showed higher prevalence among employees (28.6%) compared to students (0%). Tribal analysis revealed varying prevalence rates, with the Chaudhary tribe showing a positivity rate of 16.7%, and the Khan tribe exhibiting a positivity rate of 12.5% for hepatitis B markers. Conclusion: The findings highlight the importance of recommending hepatitis B screening for individuals with a history of jaundice, especially among older age groups and males. Understanding the differences in hepatitis B prevalence among different ethnic groups and demographics is necessary for creating effective prevention and control plans in AJK state, Pakistan. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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