| Abstrakt: |
Introduction: Stress is a ubiquitous phenomenon that affects individuals across various life stages. The orexinergic system, which is comprised of the neuropeptides orexin-A and orexin-B and their receptors, is involved in various physiological processes, including arousal, feeding, and stress response. Dysregulation of orexinergic signaling has been implicated in several neuropsychiatric disorders, including anxiety, depression, and insomnia. In this review, we focus on the stress-induced dysregulation of orexinergic signaling and its implications for stress-related disorders. We discuss the effects of acute and chronic stress on the orexinergic system, including alterations in orexinergic neuron activity and receptor expression. We also explore the potential mechanisms underlying the dysregulation of orexinergic signaling in response to stress, including glucocorticoid-mediated modulation of orexinergic neurons and alterations in the expression of downstream signaling molecules. Finally, we discuss the potential therapeutic implications of targeting the orexinergic system for stress-related disorders. Overall, this review highlights the importance of the orexinergic system in stress response and provides insights into the potential mechanisms underlying stress-induced dysregulation of orexinergic signaling. [ABSTRACT FROM AUTHOR] |
