| Autor: |
مجید عسکری پور, سوده رجبی, سهیل امینی زاده, حمید نجفی پور |
| Předmět: |
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| Zdroj: |
Koomesh: Journal of Semnan University of Medical Sciences; Sep/Oct2023, Vol. 25 Issue 5, p656-656, 2p |
| Abstrakt: |
Introduction: Chronic kidney disease (CKD) is defined as the existence of structural or functional abnormalities of one or both kidneys. The aim of this study was to investigate the effects of endurance training on oxidant and antioxidant indices in unilateral ureteral obstruction (UUO) model in ovariectomized (OVX) rats. Methods and Materials: In this study, 28 OVX female rats (n=7) were weighed and randomly divided into 4 groups: Sham, Sham+EX, UUO, UUO+EX. Endurance training with a treadmill is performed in training groups applied for 4 weeks and 5 days a week from 11:00 am to 4:00 pm every day. unilateral ureteral obstruction model was used in UUO rats for kidney damage induction. On the 29th day, the animals were anesthetized and killed, and the left kidney tissue was removed from the body and kept in a freezer at -80 to measure of kidney oxidant and antioxidant parameters. Results: UUO increased malondialdehyde and decreased superoxide dismutase, glutathione peroxidase, catalase activity and total antioxidant capacity in the obstructed kidney of OVX rats. Endurance training reversed these effects in the UUO group by increasing the antioxidant and decreasing the oxidant levels in obstructed kidney. Conclusion: Endurance training mitigated the obstructive kidney damage in OVX rats by improving the redox system. It suggested that endurance training is a useful treatment method in postmenopausal women with kidney damage. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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