| Abstrakt: |
Introduction: Due to the active ingredient prenylated flavonoids and previously shown antioxidant effects of Sophora pachycarpa (S. pachycarpa) seed extract, the aim of this study was to investigate the different effects of the fruit of this plant on the toxic effects of carbon tetrachloride on the organs, blood, and antioxidant factors of rats. Methods and Materials: Forty male Wistar rats weighing 200-250 g were randomly divided into 5 groups: group I was used as control, group II received carbon tetrachloride (CCl4) (IP, 1 mL/kg) on day 21, group III and IV received S. pachycarpa seed extract at doses of 150 mg/kg and 300 mg/kg, respectively for 21 days by oral gavage and CCl4 on day 21, group V received silymarin (300 mg/kg) for 21 days by oral gavage and CCl4 on day 21. Results: CCl4 increased the serum renal and hepatic markers including creatinine, urea, blood urea nitrogen (BUN), uric acid, alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT). Also, it significantly increased MDA levels and decreased CAT, FRAP, GSH, and SOD in the liver, testes, and kidney tissues. The use of S. pachycarpa seed extract prevented histopathological changes in a dose-dependent manner. These changes and hematological and histopathological alterations were significantly ameliorated by S. pachycarpa seed extract. Conclusion: In conclusion, the data obtained in our study confirm the protective effect of S. pachycarpa against acute exposure to CCl4-induced organ toxicity in rats, which is evidenced by improvement in hepatotoxicity, nephrotoxicity, and testicular damage. [ABSTRACT FROM AUTHOR] |
