| Autor: |
هدی پارسا, احمد علی معاضدی, الهام حویزی |
| Předmět: |
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| Zdroj: |
Koomesh: Journal of Semnan University of Medical Sciences; Sep/Oct2023, Vol. 25 Issue 5, p588-588, 2p |
| Abstrakt: |
Introduction: Alzheimer’s disease (AD) is a neurodegenerative disorder that impairs mental ability development and interrupts neurocognitive function. Despite of many years of research, there is no effective treatment. Stem cell therapy represents a fascinating new approach for the management of degenerative disorders. Methods and Materials: 28 male Wistar rats were divided into 4 groups (n=7): Control, Sham, Alzheimer’s disease model, cell therapy. The nucleus basalis of Meynert (NBM) was bilaterally destroyed using electrical lesion (0.5 mA for 3 s) in 3th and 4th groups. Sham did not undergo electrical lesion. One week after the induction of Alzheimer’s disease model, the mesenchymal cells (0.1 mL) were injected with stereotaxic surgery using a Hamilton syringe at NBM and after three weeks spatial memory was study by using Y maze. Results: our results showed significant impairment of spatial memory (p<0.01) after electrical lesion in Alzheimer’s group in compare with control and sham. Transplantation of stem cells improved spatial memory of cell therapy group in compare with Alzheimer (p<0.01). Conclusion: Based on the results obtained from the present study and the cell differentiation studies of other colleagues, it can be said that stem cells have a high ability to repair damaged tissue through differentiation into the specialized cells of the tissue in which they are implanted. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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