| Abstrakt: |
Introduction: In Iranian folk medicine, Citrus aurantium flower extract is used to treat some neural diseases.Tend to use medicinal herbs to treat diseases, is growing. This study was done to determine the effect of Citrus aurantium flowers on sleeping time and the level of anxiety in mice. Methods and Materials: In this experimental study, 80 male albino mice (25-30 g) randomly allocated in 8 groups. For measuring the sleeping time we used the Angle method and animals were divided into three experimentals (200, 400 and 600 mg/kg) and one control group. For evaluating of anxiety levels, animals randomly were divided into three experimentals and one control group, and elevated plus maze (EPM) model was used. The evaluation of anxiety indices included number and percent of time spent in open arm. Different doses of the aqueous extract of Citrus aurantium flowers (200, 400, 600 mg/kg IP) were injected intraperitoneally to the treated groups. Controls were recived 10 ml/kg/BW normal saline intraperitoneally in both methods Results: The extract of Citrus aurantium flowers (200, 400 and 600 mg/kg) significantly increased sleeping time, (P≤0.05) Also open time ( P≤0/05) and the number of open arm entries ( P≤0/05) were significantly in doses (200, 400 and 600 mg/kg) were singnificantly more than control group, respectively (P<0/05). Conclusion: This study showed that the aqueous extract of Citrus aurantium flowers incerase the sleeping time and deereasing level of anxity in mice. [ABSTRACT FROM AUTHOR] |
