| Autor: |
محمد یوسفی زردک, غلامرضا سپهری, محمد عباس بجشک, حمید نجفی پور, محمد خاکساری, فاطمه کشاورز, فاطمه سادات موسو, مرتضی غلامیسکل, علی مهیایی |
| Předmět: |
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| Zdroj: |
Koomesh: Journal of Semnan University of Medical Sciences; Sep/Oct2023, Vol. 25 Issue 5, p549-549, 2p |
| Abstrakt: |
Introduction: Lung ischemic reperfusion injury (LIRI) is a condition that occurs when the lung is reperfused after a period of inadequate blood supply. This leads to oxidative stress damage and inflammation. Quercetin, a powerful antioxidant and anti-inflammatory compound found in various fruits and vegetables. The Keap1/Nrf2 pathway is a cellular pathway that plays a crucial role in protecting cells from oxidative stress, apoptosis, and inflammation. This study aimed to investigate the effects of quercetin and its relationship with the Nrf2/Keap1/HO1 signalling pathway. Methods and Materials: Male Wistar rats were divided into four groups. Sham group, ischemia-reperfusion group (they were subjected to ischemia for 60 minutes and reperfusion for 120 minutes). Vehicle+LIR group (ethanol 5%), quercetin+LIR group: animals pre-treatment with 30 mg/kg quercetin intraperitoneally for 7 consecutive days, then underwent ischemia-reperfusion. At the end, the lung tissue was evaluated for histopathological damage and the expression of Nrt2, Keap1 and HO1 proteins. Results: Our results showed that lung Ischemia reperfusion an increase in histopathological damage indices and Keap1 protein expression. Furthermore, LIR led to decreased expression of Nrf2 and HO-1 proteins. However, the application of quercetin a decreased histopathological damage and expression of Keap1 protein, and increase in expression of Nrf2 and HO-1 proteins. Conclusion: These findings provide valuable insights into the potential therapeutic applications of quercetin in managing conditions associated with oxidative stress and tissue damage. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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