| Autor: |
مرتضی غلامی سکل, غلامرضا سپهری, محمد عباس بجشک, حمید نجفیپور, محمد خاکساری, فاطمه کشاورز, فاطمه سادات موسو, علی مهیایی, محمد یوسفی زردک |
| Předmět: |
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| Zdroj: |
Koomesh: Journal of Semnan University of Medical Sciences; Sep/Oct2023, Vol. 25 Issue 5, p548-548, 2p |
| Abstrakt: |
Introduction: Lung Ischemia-Reperfusion Injury (LIRI) is an inflammatory process associated with high mortality rates, which occurs due to the restoration of blood flow and oxygen following ischemia in lung tissue. Previous studies have shown that a flavonoid called quercetin has many effects, including anti-inflammatory effects. The objective of this study was to examine the potential anti-inflammatory properties of quercetin in shielding against inflammation resulting from lung ischemia-reperfusion in rats. Methods and Materials: Wistar rats were divided into four groups. Sham group, Ischemia reperfusion group (IR), Vehicle+ IR group (ethanol 5%), quercetin+LIR group. Animals in the quercetin+LIR group received a daily intraperitoneal dose of 30 mg/kg quercetin for one week before undergoing IR. The evaluation included assessing inflammatory mediators (Tumor necrosis factor-alpha and Interleukin-1 beta), and lung edema indices (wet/Dry weight of lung and Total protein of Bronchoalveolar fluid). Results: In the IR group, the levels of TNF-α and IL-1β, as well as the wet/dry weight of the lung and the total protein of Bronchoalveolar fluid, exhibited an increase when compared to the Sham group. However, pretreatment with quercetin prevented this elevation in inflammatory mediators and lung edema indices. Conclusion: In adult Wistar rats, Quercetin effectively reduced pro-inflammatory cytokines and indices of lung ischemia-reperfusion-induced pulmonary edema. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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