| Abstrakt: |
Introduction: Gallic acid, a phenolic compound, exhibits anti-inflammatory, antioxidant, and analgesic properties. The present study was designed to assess the anti-inflammatory property of niosomal nanoparticles loaded with gallic acid in male rats. Methods and Materials: Gallic acid-loaded niosomal nanoparticles were prepared using a thin-film hydration method and characterized for their size, zeta potential, and entrapment efficiency. After determining the optimal dose of 100 mg/kg, gallic acid-loaded niosomal nanoparticles and indomethacin (10 mg/kg) were orally administered to evaluate their impact on inflammation in rats. The anti-inflammatory effect of the treatments was assessed using the formalin-induced rat paw edema model and measured by plethysmometer method before and one hour after the injection. Results: The results indicated that the gallic acid-loaded niosomal nanoparticles had a uniform size and high entrapment efficiency for gallic acid. We observed that formalin injection induced a significant increase in paw swelling compared to the saline group. However, pre-treatment with niosomal nanoparticles loaded with gallic acid, along with indomethacin, significantly reduced the volume of inflammatory paw edema at the all time points measured, when compared to the control group. Conclusion: The results suggest that oral administration of gallic acid-loaded niosomal nanoparticles has significant anti-inflammatory activity in male rats at a level comparable to treatment with indomethacin, a standard anti-inflammatory drug. The present study suggests that gallic acid-loaded niosomal nanoparticles could be a novel drug delivery system to enhance the therapeutic efficacy of gallic acid for treating various inflammatory conditions. [ABSTRACT FROM AUTHOR] |
