| Autor: |
شهاب قادری, پارسا قلی پور, علیرضا کمکی, ایرج صالحی, خدا بخش رشیدی, سید اسماعیل خوشن, معصومه رشنو |
| Předmět: |
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| Zdroj: |
Koomesh: Journal of Semnan University of Medical Sciences; Sep/Oct2023, Vol. 25 Issue 5, p327-327, 2p |
| Abstrakt: |
Introduction: Alzheimer’s disease (AD) is the most progressive form of neurodegeneration that results in cognitive and non-cognitive disorders. Aluminum is a risk factor in the development and progression of Alzheimer’s disease. The present study was designed to determine the effects of p-coumaric acid (p-CA), a phenolic compound, on spatial cognitive ability and non-cognitive functions and to identify the role of oxidative stress and inflammation in an AD model induced by aluminum chloride (AlCl3) in rats. Methods and Materials: Both AlCl3 (100 mg/kg/day; P.O.) and p-CA (100 mg/kg/day; P.O.) treatments were given for six consecutive weeks. During the fifth and sixth weeks of the treatment, the cognitive and non-cognitive functions of the rats were assessed using standard behavioral tests. Additionally, oxidative-antioxidative status, inflammatory markers, and histological changes were evaluated in the cerebral cortex and hippocampal regions of the rats. Results: The study found that exposure to AlCl3 resulted in increased anxiety and depression-like behaviors, decreased locomotor/exploratory levels, and impaired spatial memory and learning. These cognitive and noncognitive issues were accompanied by increased oxidative stress, inflammation, and neuronal loss in the brain regions studied. However, treatment with p-CA was found to alleviate all of these negative changes in the AlCl3-induced AD rat model. Conclusion: The findings suggest that both anti-oxidative and anti-inflammatory properties of p-CA may be the underlying mechanisms behind its beneficial effect in preventing neuronal loss and improving cognitive and noncognitive deficits associated with AD. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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