| Autor: |
اعظم ابارشی, شهین مؤمن آبادی, عباسعلی وفایی, عابدین وکیلی |
| Předmět: |
|
| Zdroj: |
Koomesh: Journal of Semnan University of Medical Sciences; Sep/Oct2023, Vol. 25 Issue 5, p315-315, 2p |
| Abstrakt: |
Introduction: We have already found that post-ischemic intervention with recombinant human chemerin (rh)chemerin) can protect neurons against cerebral ischemia. In this study, we tested whether pretreatment with rh)chemerin could reduce brain damage in a model of stroke in mice. Methods and Materials: A stroke model was produced by middle cerebral artery occlusion (MCAO) for 60 minutes and 24 hours of reperfusion in mice. 23 mice were randomly divided into 3 groups, including the sham)operated group (surgery+no MCAO; n=7), the control group (MCAO+saline; n=8), the treatment group (MCAO+rh)chemerin; n=8). Rh-chemerin (800 ng/mouse) was given intranasally for 7 consecutive days before MCAO. Infarct size was assessed by the 2,3,5-triphenyl tetrazolium chloride (TTC) staining method 24 hours after ischemia. Results: The MCA blockage caused severe brain damage in the control group, which was associated with impairment in neurological functions. Pre-ischemic treatment with rh-chemerin significantly diminished infarct size and improved neurological performance (P<0.001). Conclusions: Our data indicated that rh-chemerin could help reduce brain damage if used as a pretreatment in a rodent model of stroke. This suggests that rh-chemerin may be potentially useful in patients at risk of stroke. However, the possibility of its application as a prophylaxis strategy in high-risk individuals needs more investigation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
