| Autor: |
فائزه بهرامی, حسن صدرائی, مائده قاسمی |
| Předmět: |
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| Zdroj: |
Koomesh: Journal of Semnan University of Medical Sciences; Sep/Oct2023, Vol. 25 Issue 5, p249-249, 2p |
| Abstrakt: |
Introduction: Quercetin is a flavonoid constituent of many herbal plants, including fruits, vegetables, leaves and seeds. Preclinical studies have suggested various therapeutic effects for quercetin, including protective effects on gastrointestinal motility. The Present study was performed to investigate the involvement of ATP- sensitive K+ channels (KATP) on the spasmolytic effect of quercetin on isolated ileum smooth muscle contractions. Methods and Materials: Ileum contraction were induced by KCl or acetylcholine (ACh) in vitro condition. The contractions were recorded on Harvard Universal Oscillography. The relaxant effects of the quercetin and diazoxide were examined on ileum contractions induced by the above-mentioned stimuli. The relaxant effects of quercetin and diazoxide were also examined in the presence of glibenclamide. Ileum contractions were measured as amplitude of the contraction and expressed as percentage of recorded contractions prior to addition of drug. Results: Diazoxide and quercetin in a concentration - dependent manner inhibited ileum contractions induced by low bath concentration of KCl (20mM). However, both drugs had no effect ion contractions induced by a high concentration of KCl (160mM). The antispasmodic effects of diazoxide and quercetin were blocked by glibenclamide as KATP channel blocker. Also, after adding ACh to the organ bath in the presence of different doses of quercetin, a lower contraction response was observed. At a concentration of 32 mM of quercetin, the contraction response of ACh was not observed at all. Conclusion: The results supports that ATP-sensitive K+ channels are involved in the rat ileum smooth muscles relaxation induced by quercetin. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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