| Autor: |
محمدحسین ریگی, سمیه محضری, ابوالفضل خواجوی, سارا حسینیان, فاطمه سالمی, یاسمین مروارید |
| Předmět: |
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| Zdroj: |
Koomesh: Journal of Semnan University of Medical Sciences; Sep/Oct2023, Vol. 25 Issue 5, p159-159, 2p |
| Abstrakt: |
Introduction: Adriamycin (ADR) is an antineoplastic agent whose clinical use has been limited due to nephropathy. Inflammation and oxidative stress are the main mechanisms in the pathophysiology of ADR-induced nephropathy. Sesame oil (SO) has many pharmacologic effects, including anti-inflammatory and antioxidant actions. The present study aimed to investigate the effect of SO against ADR-induced kidney dysfunction in rats. Methods and Materials: 40 male rats were randomly divided into 5 groups: 1- control, 2- adriamycin (5 mg/kg), 3- dexamethasone (0.9 mg/kg) + ADR, 4- SO (3 ml/kg) + ADR, 5- SO (6 ml/kg) + ADR. The duration of using sesame oil and dexamethasone was 6 weeks. ADR was injected on the 4th day of the experimenter, and urine samples were collected on days 1 and 42 to measure serum levels of creatinine and albumin, as well as calculate creatinine clearance and protein excretion rate. At the end of the study, animals were humanely killed, and renal tissue damage was evaluated. Results: ADR caused significant proteinuria and hypoalbuminemia and a significant decrease in serum concentration of albumin and creatinine clearance compared to the control group. Also, a significant increase in kidney tissue damage was observed following ADR injection compared to the control group. Oral administration of SO significantly reversed ADR-induced proteinuria and hypoalbuminemia compared to the ADR group. Furthermore, SO significantly improved ADR-induced tissue damage in kidney tissues compared to the ADR group. Conclusion: The current study suggests that SO can improve kidney function and ADR-induced kidney tissue damage and proteinuria in rats. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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