| Autor: |
Pineau, Benoit C., Knapple, Whit L., Spicer, K. M., Gordon, L., Wallace, M., Hennessy, Winnie S., Hawes, Robert H., Cotton, Peter B. |
| Předmět: |
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| Zdroj: |
American Journal of Gastroenterology (Springer Nature); Nov2001, Vol. 96 Issue 11, p3106-3109, 4p, 2 Charts |
| Abstrakt: |
OBJECTIVES: Cholecystokinin-stimulated hepatobiliary scintigraphy (CCK-HBS) is a noninvasive method reported to be highly accurate in the diagnosis of sphincter of Oddi dysfunction. Our primary aim was to assess the specificity of CCK-HBS by evaluating its ability to exclude disease in 20 asymptomatic postcholecystectomy individuals. Secondary aims were to assess the interobserver reliability in scoring the CCK-HBS examinations between three blinded observers and to assess reproducibility of CCK-HBS repeated in the same individuals, METHODS: Twenty asymptomatic postcholecystectomy individuals with normal liver serum chemistries underwent CCK-HBS on two separate occasions. Three nuclear medicine specialists read each CCK-HBS study in a blinded fashion. RESULTS: There was good agreement between the three observers reading the same scans for both the first scan (κ = 0.554) and the second scan (κ = 0.507), There was poor agreement between the first and second scans on the same patient, read by the same nuclear medicine specialist (κ = 0.062-0.385). The overall specificity of the CCK-HBS score was 77.5%; however, the specificity was only 60% when a true negative was defined as two negative CCK-HBS examinations. CONCLUSIONS: Quantitative CCK-HBS is of poor specificity in asymptomatic postcholecystectomy individuals. Hence, it is of questionable value in excluding sphincter of Oddi dysfunction in patients suspected to suffer from this disorder. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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