Coumarin linked to 2-phenylbenzimidazole derivatives as potent α-glucosidase inhibitors.

Autor:	Ganjeh, Mina Sadeghi, Mazlomifar, Ali, Shahvelayti, Ashraf Sadat, Moghaddam, Shiva Khalili
Předmět:	COUMARINS TYPE 2 diabetes MOLECULAR docking MOLECULES ACARBOSE
Zdroj:	Scientific Reports; 3/28/2024, Vol. 14 Issue 1, p1-10, 10p
Abstrakt:	α-Glucosidase inhibitors have emerged as crucial agents in the management of type 2 diabetes mellitus. In the present study, a new series of coumarin-linked 2-phenylbenzimidazole derivatives 5a–m was designed, synthesized, and evaluated as anti-α-glucosidase agents. Among these derivatives, compound 5k (IC50 = 10.8 µM) exhibited a significant inhibitory activity in comparison to the positive control acarbose (IC50 = 750.0 µM). Through kinetic analysis, it was revealed that compound 5k exhibited a competitive inhibition pattern against α-glucosidase. To gain insights into the interactions between the title compounds and α-glucosidase molecular docking was employed. The obtained results highlighted crucial interactions that contribute to the inhibitory activities of the compounds against α-glucosidase. These derivatives show immense potential as promising starting points for developing novel α-glucosidase inhibitors. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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