Establishing conditions for the generation and maintenance of estrogen receptor-positive organoid models of breast cancer.

Autor:	Oliphant, Michael U J, Akshinthala, Dipikaa, Muthuswamy, Senthil K.
Předmět:	BREAST cancer ESTROGEN HORMONE therapy NATURAL immunity DISEASE progression HORMONE receptor positive breast cancer
Zdroj:	Breast Cancer Research; 3/29/2024, Vol. 26 Issue 1, p1-7, 7p
Abstrakt:	Patient-derived organoid models of estrogen receptor-positive (ER+) breast cancer would provide a much-needed tool to understand drug resistance and disease progression better. However, the establishment and long-term maintenance of ER expression, function, and response in vitro remains a significant challenge. Here, we report the development of an ER+ breast tumor organoid medium (BTOM-ER) that conserves ER expression, estrogen responsiveness, and dependence, as well as sensitivity to endocrine therapy of ER+ patient-derived xenograft organoids (PDXO). Our findings demonstrate the utility of subtype-specific culture conditions that better mimic the characteristics of the breast epithelial biology and microenvironment, providing a powerful platform for investigating therapy response and disease progression of ER+ breast cancer. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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