| Autor: |
Bazzoli, Franco, Cecchini, Liliana, Corvaglia, Luigi, Dall'Antonia, Martino, De Giacomo, Costantino, Fossi, Stefania, Casali, Luigi Gobio, Gullini, Sergio, Lazzari, Rosanna, Leggeri, Giorgio, Lerro, Pietro, Valdambrini, Valeria, Mandrioli, Gianni, Marani, Miris, Martelli, Paolo, Miano, Angelo, Nicolini, Gianni, Oderda, Giuseppina, Pazzi, Paolo, Pozzato, Paolo |
| Předmět: |
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| Zdroj: |
American Journal of Gastroenterology (Springer Nature); Mar2000, Vol. 95 Issue 3, p646-650, 5p, 4 Charts, 2 Graphs |
| Abstrakt: |
OBJECTIVE: The 13C-urea breath test (13C-UBT) is a safe. noninvasive, and accurate test for the detection of Helicobacter pylori (H. pylori) infection in adults. The aim of this study was to evaluate sensitivity and specificity of 13C-UBT in children using different types of test meal, doses of 13C-urea and breath sampling intervals. As yet, a validated, standardized 13C-UBT protocol for children has not been formulated. METHODS: 13C-UBT was performed in 115 children and repented within 3 days, modifying the test meal or the dose of 13C-urea. H. pylori status was assessed by histology and rapid urease test. 13C-UBT was performed using 100 mg or 50 mg of 13C-urea and a fatty test meal (100 FA; 50 FA). 50 mg of 13C-urea, and a carbohydrate test meal (50 CA). Breath samples were collected every 10 min for 60 min. RESULTS: The 13C-UBT in children was highly sensitive and specific with all three protocols used. The best combination of sensitivity (97.92%) and specificity (97.96%) was obtained with Protocol 50 FA at 30 min with a cut-off of 3.5 per mil. CONCLUSIONS: The 13C-UBT is an accurate test for the detection of H. pylori infection also in children. Administration of 50 mg of 13C-urea, a fatty test meal, and breath sampling at 30 min appears to be the most convenient protocol. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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