| Předmět: |
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| Zdroj: |
Cancer Vaccine Week; 4/1/2024, p108-108, 1p |
| Abstrakt: |
Researchers from Durham, North Carolina have conducted a study on the potential of tumor-associated circular RNAs (circRNAs) as a source of neoepitopes in microsatellite-stable colorectal cancer (CRC). Using various databases and assays, they identified neoepitopes from circRAPGEF5 and circMYH9 that elicited an antigen-specific T cell response and expansion. T cells trained with circMYH9 peptides were able to specifically target and eliminate tumor-derived organoids. The researchers concluded that tumor-associated circRNAs could serve as an alternative source of neoantigens for cancer vaccines targeting tumors with moderate mutation levels. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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