| Abstrakt: |
A study conducted at Northeast Agricultural University in Harbin, China, has found that the common phthalate chemical di-(2-ethylhexyl) phthalate (DEHP) can cause neurotoxicity by disrupting the interaction between the endoplasmic reticulum (ER) and mitochondria in the brain. DEHP exposure led to morphological changes, motor deficits, cognitive impairments, and disruption of the blood-brain barrier. The study suggests that the disruption of the Mfn2-PERK axis-mediated ER-mitochondria interaction could potentially be targeted for the development of novel therapies for neurological diseases. The research was funded by various organizations in China and has been peer-reviewed. [Extracted from the article] |
