S100A8/A9 as a prognostic biomarker with causal effects for post-acute myocardial infarction heart failure.

Autor: Ma, Jie, Li, Yang, Li, Ping, Yang, Xinying, Zhu, Shuolin, Ma, Ke, Gao, Fei, Gao, Hai, Zhang, Hui, Ma, Xin-liang, Du, Jie, Li, Yulin
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Zdroj: Nature Communications; 3/27/2024, Vol. 15 Issue 1, p1-13, 13p
Abstrakt: Heart failure is the prevalent complication of acute myocardial infarction. We aim to identify a biomarker for heart failure post-acute myocardial infarction. This observational study includes 1062 and 1043 patients with acute myocardial infarction in the discovery and validation cohorts, respectively. The outcomes are in-hospital and long-term heart failure events. S100A8/A9 is screened out through proteomic analysis, and elevated circulating S100A8/A9 is independently associated with heart failure in discovery and validation cohorts. Furthermore, the predictive value of S100A8/A9 is superior to the traditional biomarkers, and the addition of S100A8/A9 improves the risk estimation using traditional risk factors. We finally report causal effect of S100A8/A9 on heart failure in three independent cohorts using Mendelian randomization approach. Here, we show that S100A8/A9 is a predictor and potentially causal medicator for heart failure post-acute myocardial infarction. Heart failure is the most prevalent complication of acute myocardial infarction. Here, the authors show that circulating S100A8/A9 is a robust predictor and potentially causal medicator for heart failure post-acute myocardial infarction, as such could serve as a promising drug target for cardioprotection. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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