| Autor: |
N. S., Rakshitha, S., Sachin, Balappa, Govinda, Maddimani, Ramesh S., H., Sivaranjani |
| Předmět: |
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| Zdroj: |
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research); 2024, Vol. 15 Issue 2, p10-18, 9p |
| Abstrakt: |
INTRODUCTION: Chronic Obstructive Pulmonary Disease (COPD) is currently the fourth leading cause of death in the world. Acute exacerbation of COPD are most commonly triggered by respiratory infections predominantly viral although bacterial infections as well as environmental triggers can initiate these events. Recent studies have indicated. B-type natriuretic peptide(BNP) is a valuable asset in predicting the severity of chronic obstructive pulmonary disease and outcomes as well. OBJECTIVES: The objectives of this study are to measure the levels of Brain Natriuretic Peptide (BNP) in patients experiencing acute exacerbations of chronic obstructive pulmonary disease (COPD) and to evaluate the relationship between BNP levels, the staging of COPD, and in-hospital outcomes. METHODOLOGY: The Study is a hospital based prospective study conducted on 110 patients presenting with Acute exacerbation of COPD satisfying inclusion and exclusion criteria admitted in hospitals attached to Bangalore Medical College & Research Institute. All necessary investigations were done. Plasma BNP levels were measured during initial presentation and patients were followed up until discharge or death. RESULTS: Among 110 patients with acute exacerbation of COPD, 20 (18.2%) were females and 90 (81.8%) were males. The mean plasma BNP level was 121.31 pg/ml (SD-48.29). The present study shows that BNP levels in acute exacerbation of COPD increases as the severity of COPD increases (r-0.786) (p= <0.01). The mean duration of hospitalization was 5.18 days. The mean BNP was higher in patients who were managed with non invasive (163.7pg/ml) and invasive ventilation(271.7pg/ml) than on just oxygen supplementation via face masks (107.0 pg/ml). BNP levels during acute exacerbation was significantly higher among nonsurvivors (286.7pg/ml) than survivors (119.8pg/ml). INTERPRETATION AND CONCLUSION: BNP levels are elevated during acute exacerbation of COPD and can be used as an indicator of severity of COPD exacerbations. BNP levels are can be used for prediction of poor prognosis and mortality during acute exacerbation of COPD. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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