| Abstrakt: |
Background: Arteriosclerosis and its sequelae are the most common cause of death in diabetic patients and one of the reasons why diabetes has entered the top 10 causes of death worldwide, fatalities having doubled since 2000. The literature in the field claims almost unanimously that arteriosclerosis is more frequent or develops more rapidly in diabetic than non-diabetic subjects, and that the disease is caused by arterial inflammation, the control of which should therefore be the goal of therapeutic efforts. Methodology: A Cross sectional Observational study conducted in the Dept. of General Medicine. All newly diagnosed patients of Diabetes mellitus, attending diabetes OPD, AGMC & GBPH, subjected to inclusion and exclusion criteria. By census method, all the newly diagnosed type 2 diabetes mellitus patients visiting Diabetes OPD, AGMC & GBPH are considered for the study till the sample size is reached. Results: Multivariable logistic regression analysis was done to find the Variables influencing the Atherosclerosis, after adjusting the risk for other variables, with CIMT-high risk as dependent variable. In the present study population Triglycerides, HbA1c are found to be strongest predictors of atherosclerosis (p<0.001). VLDL are also affecting CIMT. After adjustment, S Ch, LDL not significance (p=0.21, p=0.61 respectively) in relation to CIMT and HDL (p=0.30 influence on CIMT is not significant. Conclusion: HbA1c is found to be the strongest predictor along with triglycerides, VLDL, but not the S.cholesterol, LDL & HDL. So, whenever newly diagnosed type 2 diabetes is presented, patient should be evaluated for the atherosclerosis, even in the absence of dyslipidemia and obesity, especially in a patient with poor glycemic control and older age males. It is justified to subject such patients for CIMT analysis. If found to be high risk it can be considered risk marker if not risk factor. [ABSTRACT FROM AUTHOR] |
