| Abstrakt: |
Objective: To explore the epidemiological characteristics of hyperuricemia (HUA) in the metabolic syndrome (MS) and its different components in the physical examination population. Methods: Subjects who underwent medical check-ups at a hospital health management center from June 2021 to March 2023 were included in the study. To analyze the prevalence of HUA in MS and its different components, further, stratify the study population by gender and assess the serum uric acid (SUA) levels and prevalence of HUA in people with different numbers of MS components and the combination of MS components with the highest prevalence of HUA in both sexes. Logistic regression was used to analyze the risk of HUA in people with different numbers of MS components. Result: A total of 66,520 individuals were enrolled in the study. SUA levels (t= -82.947, P<0.001) and HUA prevalence (χ2 = 3421.632, P<0.001) were significantly higher in the MS group than in the Non-MS group. SUA levels and prevalence of HUA were significantly higher in abdominal obesity, hypertension, decreased HDL-C and evaluated TG than in normal subjects (P<0.001), while there were gender differences in SUA levels and HUA prevalence in diabetic patients, with significantly lower SUA levels and HUA prevalence in men with diabetes than in those with normal blood glucose, an opposite result in women. SUA levels and HUA prevalence gradually increased with the increasing number of MS components in women, whereas in men, such a trend was only observed in MS1-MS4. The combination of MS components with the highest prevalence of HUA was abdominal obesity + hypertension + decreased HDL-C + evaluated TG (54.35%) in men and abdominal obesity + hypertension + diabetes + decreased HDL-C + evaluated TG (41.46%) in women. Logistic regression analysis showed that after adjusting for gender, age and ethnicity, the risk of HUA increased with the number of MS components in women, while in men, the risk of HUA increased continuously from MS1-MS4. Further adjustment for BMI, elevated TC, elevated LDL-C, and coronary artery disease, the results remained consistent. Conclusion: MS and its components are risk factors for HUA in the physical examination population, with different combinations of MS components having different correlations with HUA, and the risk of developing HUA correlates with the number of abnormal MS components. [ABSTRACT FROM AUTHOR] |
