| Autor: |
Lopes, Bruna, Coelho, André, Alvites, Rui, Sousa, Ana Catarina, Sousa, Patrícia, Moreira, Alícia, Atayde, Luís, Salgado, António, Geuna, Stefano, Maurício, Ana Colette |
| Zdroj: |
Regenerative Medicine; Apr2024, Vol. 19 Issue 4, p189-203, 15p |
| Abstrakt: |
Aim: Peripheral nerve injury regeneration studies using animal models are crucial to different pre-clinical therapeutic approaches efficacy evaluation whatever the surgical technique explored. Materials & methods: A 944 articles systematic review on 'peripheral nerve injury in animal models' over the last 9 years was carried out. Results: It was found that 91% used rodents, and only 9% employed large animals. Different nerves are studied, with generated gaps (10,78 mm) and methods applied for regeneration evaluation uniformed. Sciatic nerve was the most used (88%), followed by median and facial nerves (2.6%), significantly different. Conclusion: There has not been a significant scale-up of the in vivo testing to large animal models (anatomically/physiologically closer to humans), allowing an improvement in translational medicine for clinical cases. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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