Studies in the Area of HIV/AIDS Reported from Shandong University (Structure-based design and optimization lead to the identification of novel dihydrothiopyrano[3,2-d]pyrimidine derivatives as potent HIV-1 inhibitors against drug-resistant...).

Předmět:	AIDS HIV PYRIMIDINE derivatives SEXUALLY transmitted diseases KINASE inhibitors REVERSE transcriptase inhibitors INTEGRASE inhibitors
Zdroj:	AIDS Weekly; 2024, p103-103, 1p
Abstrakt:	A study conducted at Shandong University in China has discovered a class of nonnucleoside reverse transcriptase inhibitors that show promising antiviral activity against HIV-1, including drug-resistant strains. The most potent inhibitor, compound 23h, demonstrated significant activity against challenging double-mutant strains and showed improved resistance profiles compared to current first-line drugs. The study also confirmed that compound 23h targets HIV-1 reverse transcriptase and has good pharmacokinetic properties and safety in vivo. This research suggests that compound 23h has the potential to be an effective antiviral agent for HIV/AIDS treatment. [Extracted from the article]
Databáze:	Complementary Index
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