| Abstrakt: |
A recent study conducted by researchers at the University of Rochester Medical Center explores the dysregulation of extracellular potassium in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), and Huntington's disease (HD). The study found that cortical extracellular potassium concentration was consistently elevated in models of these diseases, while aged wildtype mice exhibited lower levels of cortical extracellular potassium. The researchers suggest that the dysregulation of extracellular potassium homeostasis may be due to aberrant astrocytic potassium buffering, highlighting the role of glial dysfunction in neurodegeneration. Further research is needed to fully understand the underlying mechanisms. [Extracted from the article] |
