Self-sampled multi-anatomic site testing for uncovering the community burden of undiagnosed Chlamydia trachomatis and Neisseria gonorrhoeae infection in men who have sex with men.

Autor:	Wong, Ngai Sze, Chan, Denise Pui-Chung, Chung, Sze Long, Kwan, Tsz Ho, Lee, Krystal Chi-Kei, Kwan, Chi Keung, Lee, Shui Shan
Předmět:	CHLAMYDIA infection diagnosis RESEARCH funding LOGISTIC regression analysis DISEASE prevalence DESCRIPTIVE statistics CHLAMYDIA trachomatis MEN who have sex with men LONGITUDINAL method SURVEYS CHLAMYDIA infections PHARYNX ODDS ratio NEISSERIA infections COLLECTION & preservation of biological specimens URINE collection & preservation DATA analysis software CONFIDENCE intervals PATIENT self-monitoring SELF diagnosis RECTUM
Zdroj:	Infection; Apr2024, Vol. 52 Issue 2, p491-502, 12p
Abstrakt:	Purpose: To detect otherwise undiagnosed asymptomatic sexually transmitted infection (STI), and for estimating prevalence among men who have sex with men (MSM). Methods: In this community-based study in Hong Kong, adult MSM were recruited. After completion of an online survey, free multi-anatomic sites self-sampling kits (urine specimens, pharyngeal and rectal swabs) for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) tests were delivered to requesting participants. Factors associated with STI positivity were analyzed in logistic regression. Results: From September 2021 to October 2022, 712 MSM were recruited, with 86% aged 18–39, and 16% reported history of chemsex engagement. A majority (81%) had previously undergone HIV testing, 68% had ever tested for STI, and 35% previously diagnosed with STI. Totally 428 (60%) had requested self-sampling kits, and 276 (39%) returned collected samples. Among participants who returned the samples, about half had never been tested in the past and had no history of STI. Overall 21% tested positive for CT and/or NG (CT/NG)—CT positive 16% and NG positive 7%. By anatomic site, 16% of rectal swabs, 7% of pharyngeal swabs, but just 3% of urine specimens were CT/NG positive. The prevalence of CT/NG was not significantly different by history of STI diagnosis and testing. Conclusion: Self-sampled STI testing is a potentially useful means for enhancing uptake of screening in MSM in the community, which could uncover otherwise undiagnosed asymptomatic infections. Internet-based self-sampling for STI testing could complement the current clinic-based STI testing for supporting epidemiologic evaluation of STI control in the community. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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