Gene polymorphisms of molecules of the cGAS-STING signalling pathway are associated with AML in Chinese patients.

Autor:	Ma, Yuechan, Wang, Dongmei, Feng, Lei, Chang, Mengyuan, Li, Mingying, Meng, Guangqiang, Wu, Yuyan, Lu, Fei, Sun, Tao, Ji, Chunyan, Ye, Jingjing
Předmět:	RNA analysis DNA analysis LEUKOCYTE count RESEARCH funding ACADEMIC medical centers PLATELET count FISHER exact test LOGISTIC regression analysis HEMOGLOBINS CELLULAR signal transduction TUMOR markers CHI-squared test REVERSE transcriptase polymerase chain reaction DESCRIPTIVE statistics CANCER patients GENETIC carriers LOG-rank test KAPLAN-Meier estimator ODDS ratio GENE expression MESSENGER RNA DRUG efficacy MASS spectrometry DISEASE susceptibility GENETIC techniques SURVIVAL analysis (Biometry) CONFIDENCE intervals COLLECTION & preservation of biological specimens DATA analysis software SINGLE nucleotide polymorphisms INDUCTION chemotherapy OVERALL survival GENOTYPES
Zdroj:	Holistic Integrative Oncology; 3/19/2024, Vol. 3 Issue 1, p1-10, 10p
Abstrakt:	Purpose: The aim of this study was to explore the relationships between single-nucleotide polymorphisms (SNPs) of crucial molecules in the cGAS-STING signalling pathway and the susceptibility to, induction chemotherapy response of, and prognosis of acute myeloid leukaemia (AML) in Chinese patients. Methods: Thirteen SNPs of crucial molecules in the cGAS-STING signalling pathway were genotyped in 262 AML patients using the Sequenom MassARRAY system. The associations of SNPs with susceptibility, and induction chemotherapy response were analysed using the chi-square test or Fisher's exact test and univariate binary logistic regression, the connection of SNPs with prognosis of AML was analysed using the log-rank test, and Kaplan–Meier curves were applied for survival estimation. Results: In our study, gene polymorphisms of cGAS-STING signalling pathway molecules could be vitally associated with AML. In the recessive model, the cGAS rs311678 gene polymorphism could be closely related to AML susceptibility (CC vs. TT + TC, odds ratio (OR) = 0.480, 95% confidence interval (CI) = 0.260–0.889, p = 0.020). Moreover, IKKA rs3808917 might be associated with the WBC count, cGAS rs311678 could be associated with the bone marrow (BM) blast percentage, and NF-κB rs1056890 under codominant and recessive models could be connected with the HGB level. Patients who were STING rs7380272 TT/CT carriers was likely to have higher insensitivity to induction chemotherapy than CC carriers (TT + CT vs. CC, OR = 2.917, 95% CI = 1.073–7.929, p = 0.036). Survival analysis indicated that the IKKB rs3747811 TT genotype might be associated with decreased overall survival (OS) (p < 0.05). Conclusions: SNPs of molecules in the cGAS-STING signalling pathway could be significantly associated with AML. The cGAS rs311678 gene polymorphism could be associated with AML susceptibility, the STING rs7380272 variant might be related to induction chemotherapy response, and IKKB rs3747811 tended to be associated with AML overall survival. Moreover, IKKA rs3808917 could be associated with the WBC count, cGAS rs311678 could be associated with the BM blast percentage, and NF-κB rs1056890 might be related to the HGB level. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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