| Autor: |
Drouin, Arnaud, Plumb, Ian D., McCullough, Matthew, James Gist, Jade, Liu, Sharon, Theberge, Marc, Katz, Joshua, Moreida, Matthew, Flaherty, Shelby, Chatwani, Bhoomija, Briggs Hagen, Melissa, Midgley, Claire M., Fusco, Dahlene |
| Předmět: |
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| Zdroj: |
Scientific Reports; 3/19/2024, Vol. 14 Issue 1, p1-12, 12p |
| Abstrakt: |
Louisiana experienced high morbidity and mortality from COVID-19. To assess possible explanatory factors, we conducted a cohort study (ClinSeqSer) of patients hospitalized with COVID-19 in New Orleans during August 2020–September 2021. Following enrollment, we reviewed medical charts, and performed SARS-CoV-2 RT-PCR testing on nasal and saliva specimens. We used multivariable logistic regression to assess associations between patient characteristics and severe illness, defined as ≥ 6 L/min oxygen or intubation. Among 456 patients, median age was 56 years, 277 (60.5%) were Black non-Hispanic, 436 (95.2%) had underlying health conditions, and 358 were unvaccinated (92.0% of 389 verified). Overall, 187 patients (40.1%) had severe illness; 60 (13.1%) died during admission. In multivariable models, severe illness was associated with age ≥ 65 years (OR 2.08, 95% CI 1.22–3.56), hospitalization > 5 days after illness onset (OR 1.49, 95% CI 1.01–2.21), and SARS CoV-2 cycle threshold (Ct) result of < 32 in saliva (OR 4.79, 95% CI 1.22–18.77). Among patients who were predominantly Black non-Hispanic, unvaccinated and with underlying health conditions, approximately 1 in 3 patients had severe COVID-19. Older age and delayed time to admission might have contributed to high case-severity. An association between case-severity and low Ct value in saliva warrants further investigation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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