| Autor: |
Spanò, Giulia, Pehlivanoğlu, Selen, Windt, Leon J De |
| Předmět: |
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| Zdroj: |
Cardiovascular Research; Jan2024, Vol. 120 Issue 1, p10-12, 3p |
| Abstrakt: |
This article discusses the role of RNA alternative splicing in regulating cardiomyocyte contraction and cardiac function. It draws a parallel between the complexity of the human transcriptome and the mythical Hydra, highlighting the various layers of regulation involved in gene expression. The study focuses on the RNA binding protein RBPMS and its function in splicing regulation. The researchers used genetic manipulation techniques to study the effects of RBPMS deletion in mice and human induced pluripotent stem cell-derived cardiomyocytes, revealing its importance in maintaining cardiac morphology and function. The findings provide valuable insights into the splicing machinery and its potential implications for understanding and treating cardiac diseases. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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