Continuous flow reactions in the preparation of active pharmaceutical ingredients and fine chemicals.

Autor: Martins, Guilherme M., Braga, Felipe C., de Castro, Pedro P., Brocksom, Timothy J., de Oliveira, Kleber T.
Předmět:
Zdroj: Chemical Communications; 3/25/2024, Vol. 60 Issue 24, p3226-3239, 14p
Abstrakt: Herein, we present an overview of continuous flow chemistry, including photoflow and electroflow technologies in the preparation of active pharmaceutical ingredients (APIs) and fine chemical intermediates. Examples highlighting the benefits and challenges associated with continuous flow processes, mainly involving continuous thermal, photo- and electrochemical transformations, are drawn from the relevant literature, especially our experience and collaborations in this area, with emphasis on the synthesis and prospective scale-up. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index