| Abstrakt: |
A new study conducted by the National Institute of Allergy and Infectious Diseases (NIAID) explores the cellular response of midgut progenitors to Plasmodium berghei infection in Anopheles stephensi mosquitoes. The research found that the presence of developing oocysts triggers the proliferation of midgut progenitors, which is modulated by the Jak/STAT pathway. Silencing components of key signaling pathways decreased oocyst numbers, while limiting progenitor cell proliferation increased oocyst survival. The study concludes that midgut progenitors mount a cellular defense response that involves proliferation, tissue remodeling, and the elimination of oocysts by enteroblasts. [Extracted from the article] |
