Study Findings on Nanoparticles Reported by a Researcher at Carnegie Mellon University (Lipid nanoparticle structure and delivery route during pregnancy dictate mRNA potency, immunogenicity, and maternal and fetal outcomes).

Předmět:	NANOPARTICLES RESEARCH personnel IMMUNE response MESSENGER RNA LIPIDS
Zdroj:	Drug Week; 3/19/2024, p2944-2944, 1p
Abstrakt:	A recent study conducted at Carnegie Mellon University explored the use of lipid nanoparticle (LNP) RNA therapies for treating pregnancy-related disorders. The researchers found that LNPs can effectively deliver mRNA to maternal organs in pregnant mice through various routes of administration. However, they also discovered that certain LNP structures and routes of administration can lead to maternal inflammatory responses and hinder neonatal development. The study provides valuable insights into the design of safe and potent LNPs for use during pregnancy. [Extracted from the article]
Databáze:	Complementary Index
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