| Předmět: |
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| Zdroj: |
Genomics & Genetics Weekly; 3/22/2024, p2312-2312, 1p |
| Abstrakt: |
A recent study conducted by researchers at Xinxiang Medical University in China explored the use of synthetic enhancers to improve the production of recombinant therapeutic proteins (RTPs) in CHO cells. The researchers evaluated five synthetic enhancers, including multiple transcription factor regulatory elements (TFREs), and found that four of them significantly enhanced the expression of report genes in both transient and stably transfected CHO cells. The study also investigated the effect of these enhancers on human serum albumin (HSA) and found that they increased transient expression by up to 1.5 times and stable expression by up to 2.14 times. The researchers concluded that optimizing enhancers in the CMV promoter could increase the production yield of transgenes in CHO cells, which is important for developing high-yield CHO cell expression systems. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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