Research Study Findings from University of North Carolina Update Understanding of Glioblastomas (Trans-lesion synthesis and mismatch repair pathway crosstalk defines chemoresistance and hypermutation mechanisms in glioblastoma).

Předmět:	GLIOBLASTOMA multiforme DRUG resistance in cancer cells DNA repair
Zdroj:	Genomics & Genetics Weekly; 3/22/2024, p1095-1095, 1p
Abstrakt:	A recent study conducted by researchers at the University of North Carolina has shed light on the mechanisms behind chemoresistance and hypermutation in glioblastomas (GBM), a type of brain cancer. The study found that the E3 ubiquitin ligase RAD18 plays a crucial role in promoting post-replicative gap-filling and survival in GBM cells treated with the chemotherapeutic drug temozolomide (TMZ). The researchers also discovered a correlation between low RAD18 expression and hypermutation in recurrent GBM patient samples. These findings provide valuable insights into the molecular underpinnings of TMZ-treated GBM and could potentially inform the development of more effective treatment strategies. [Extracted from the article]
Databáze:	Complementary Index
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