| Abstrakt: |
A recent study conducted by researchers at Baylor University College of Medicine in Houston, Texas, explores the relationship between chronic circadian dysfunction and non-alcoholic fatty liver disease (NAFLD)-related hepatocellular carcinoma (HCC). The study used a mouse model with humanized livers to investigate the mechanisms behind NAFLD-related carcinogenesis and HCC progression. The findings suggest that chronic circadian dysfunction can drive the development of NAFLD-related HCCs and HCC metastasis, independent of diet. The study also identified specific bile acids as prognostic biomarkers for hepatocarcinogenesis. The research provides valuable insights into the impact of circadian disruption on hepatocarcinogenesis and potential anti-HCC therapies. [Extracted from the article] |
